LymphedemaV1, Main, Exploration, bibRecord, 00A977

Proinflammatory cytokines secreted by monocytes of filarial patients.

Identifieur interne : 00A977 ( Main/Exploration ); précédent : 00A976; suivant : 00A978

Proinflammatory cytokines secreted by monocytes of filarial patients.

Auteurs : U. Raman [Inde] ; D. Eswaran ; R B Narayanan ; K. Jayaraman ; P. Kaliraj

Source :

Microbiology and immunology [ 0385-5600 ] ; 1999.

RBID : pubmed:10338198

Descripteurs français

KwdFr :
- Animaux, Antigènes d'helminthe, Brugia malayi (immunologie), Cytokines (sécrétion), Filariose lymphatique (immunologie), Humains, Microfilaria (immunologie), Monocytes (immunologie), Monocytes (sécrétion), Protéines recombinantes, Setaria (nématode) (immunologie).
MESH :
- immunologie : Brugia malayi, Filariose lymphatique, Microfilaria, Monocytes, Setaria (nématode).
- sécrétion : Cytokines, Monocytes.
- Animaux, Antigènes d'helminthe, Humains, Protéines recombinantes.

English descriptors

KwdEn :
- Animals, Antigens, Helminth, Brugia malayi (immunology), Cytokines (secretion), Elephantiasis, Filarial (immunology), Humans, Microfilariae (immunology), Monocytes (immunology), Monocytes (secretion), Recombinant Proteins, Setaria Nematode (immunology).
MESH :
- chemical , secretion : Cytokines.
- chemical : Antigens, Helminth, Recombinant Proteins.
- immunology : Brugia malayi, Elephantiasis, Filarial, Microfilariae, Monocytes, Setaria Nematode.
- secretion : Monocytes.
- Animals, Humans.

Abstract

The levels of interleukin 1, granulocyte macrophage colony stimulating factor (GM-CSF) and tumour necrosis factor (TNF)-alpha secreted by the monocytes of filarial patients, such as asymptomatic microfilaremics (MF), chronic pathology (CP), and normal individuals, residing in a Wuchereria bancrofti endemic area (EN) in response to whole Brugia malayi antigen (BmA) and Setaria digitata (Sd-cuticular) and a recombinant filarial antigen (pRJ51) were studied. Stimulation of peripheral blood adherent cells with whole parasite antigen showed marked increase in IL-1 levels in MF as compared to CP or EN. The recombinant antigen stimulation, however, resulted in similar levels of IL-1 in MF and CP. In contrast, stimulation of peripheral blood adherent cells with whole parasite antigen produced high levels of GM-CSF and TNF-alpha in CP as opposed to MF or EN. Recombinant antigen stimulation, however, produced high levels of GM-CSF in EN as compared to MF or CP, while no significant change in the release of TNF-alpha was observed in these patients. These results suggest that monocytes from filarial patients exhibit functional activity similar to that observed by the monocytes of endemic normals (control group).

PubMed: 10338198

Affiliations:

Inde

Le document en format XML

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<term>Elephantiasis, Filarial (immunology)</term>
<term>Humans</term>
<term>Microfilariae (immunology)</term>
<term>Monocytes (immunology)</term>
<term>Monocytes (secretion)</term>
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<term>Filariose lymphatique (immunologie)</term>
<term>Humains</term>
<term>Microfilaria (immunologie)</term>
<term>Monocytes (immunologie)</term>
<term>Monocytes (sécrétion)</term>
<term>Protéines recombinantes</term>
<term>Setaria (nématode) (immunologie)</term>
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<term>Setaria Nematode</term>
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<front><div type="abstract" xml:lang="en">The levels of interleukin 1, granulocyte macrophage colony stimulating factor (GM-CSF) and tumour necrosis factor (TNF)-alpha secreted by the monocytes of filarial patients, such as asymptomatic microfilaremics (MF), chronic pathology (CP), and normal individuals, residing in a Wuchereria bancrofti endemic area (EN) in response to whole Brugia malayi antigen (BmA) and Setaria digitata (Sd-cuticular) and a recombinant filarial antigen (pRJ51) were studied. Stimulation of peripheral blood adherent cells with whole parasite antigen showed marked increase in IL-1 levels in MF as compared to CP or EN. The recombinant antigen stimulation, however, resulted in similar levels of IL-1 in MF and CP. In contrast, stimulation of peripheral blood adherent cells with whole parasite antigen produced high levels of GM-CSF and TNF-alpha in CP as opposed to MF or EN. Recombinant antigen stimulation, however, produced high levels of GM-CSF in EN as compared to MF or CP, while no significant change in the release of TNF-alpha was observed in these patients. These results suggest that monocytes from filarial patients exhibit functional activity similar to that observed by the monocytes of endemic normals (control group).</div>
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Serveur d'exploration sur le lymphœdème

Proinflammatory cytokines secreted by monocytes of filarial patients.

Proinflammatory cytokines secreted by monocytes of filarial patients.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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